Dr. Guy Luthan (Hugh Grant) confronts a medical mystery that seems beyond his skills as an Emergency Room physician. His search for answers surrounding the bizarre death of a homeless man takes him into the dark frontiers of medical research and to a confrontation with Dr. Lawrence Myrick (Gene Hackman), one of the country's most revered medical figures. Now, his credibility, career and life are all at risk, as he forces everyone to take extreme measures.