It has been years since the original Killer Tomato attack was squashed, and pizza-makers Matt (George Clooney) and Chad (Anthony Starke) are living a life ripe with good times and non-tomato based sauces. Meanwhile, mad genetic scientist Professor Gangreen (John Astin) is plotting to take over the world by creating a race of mighty tomato warriors and one wanton tomato woman (Karen Mistal). But when Chad falls in love with the bodacious tomato babe, he and Matt must face a deadly rampage of ninjas, newsmen, toxic waste and product placement. Can these two heroes defeat the most fiendish red menace of all or will the girl of their dreams turn out be a complete vegetable?