A legendary vampire Lestat (Stuart Townsend) reinvents himself as a rock star. His music wakes Akasha (Aaliyah), the queen of all vampires, whose malevolent power is so great that all the immortal vampires must stand against her if they hope to survive. As Lestat's music inspires Akasha to make him her king, Jesse (Marguerite Moreau), a young woman with a fascination for the dark side, falls in love with Lestat.