A top FBI profiler, Special Agent Illeana Scott (Angelina Jolie) doesn't rely on traditional crime-solving techniques to unravel the mysteries of a murderous mind. When Montreal detectives handling a local homicide investigation reluctantly ask for an outsider's help to get inside the head of a cunning serial killer, Agent Scott joins the case. As the pressure mounts to catch the elusive murderer, Agent Scott's unorthodox methods alienate her from a territorial police team that feels threatened by her uncanny abilities. Alone in an unfamiliar city with no one she can trust, Agent Scott suddenly finds herself on a twisted and terrifying journey, surrounded by suspects in a case that has become chillingly personal.