The world's most wanted master thief, Lupin the Third is dead! Despite a coroner's report, Inspector Zenigata is skeptical and discovers that Lupin is actually alive and well and stealing! But who had set up Lupin's death and why? Meanwhile, Fujiko is lured by the promise of eternal youth and beauty by the mad scientist know as Mamo. Pursuing Fujiko leads Lupin and his gang to Mamo's hideaway, where they discover the madman's dark secret and a fiendish scheme that threatens the entire planet! Now, it's up to Lupin to stop the insane Mamo-before he can complete his 10,000 year-old plans of world domination.