A love story set against the backdrop of the 1960s amid the turbulent years of anti-war protest, mind exploration and rock 'n roll, the film moves from the dockyards of Liverpool to the creative psychedelia of Greenwich Village, from the riot-torn streets of Detroit to the killing fields of Vietnam. The star-crossed lovers, Jude (Jim Sturgess) and Lucy (Evan Rachel Wood), along with a small group of friends and musicians, are swept up into the emerging anti-war and counterculture movements, with "Dr. Robert" (Bono) and "Mr. Kite" (Eddie Izzard) as their guides. Tumultuous forces outside their control ultimately tear the young lovers apart, forcing Jude and Lucy against all odds to find their own way back to each other.

Jim Sturgess, Evan Rachel Wood, Joe Anderson, Dana Fuchs, Cynthia Loebe, Martin Luther, T.V. Carpio, Heather Janneck, Salma Hayek, Eddie Izzard, Bono, Jacob Pitts, James Urbaniak, Robert Clohessy, Samantha Futerman, Kevin Watson, Tracey Brennan, Linda Emo