As its 23 horrifying days of flesh-eating come to an end, an ancient creature known as the Creeper embarks on a final voracious feeding frenzy, terrorizing a group of varsity basketball players, cheerleaders, and coaches stranded on a remote highway after their bus breaks down. Fighting their own fears and prejudices while trapped aboard the isolated bus, the terrified group of young athletes are forced to come together and do battle against the winged creature hell bent on completing its grizzly ritual of feasting on humans.