Super High Me features comedian Doug Benson and explores the current situation with medical marijuana in California and the United States, specifically focusing on the conflict between federal and state law and the explosive growth in medical marijuana dispensaries in Los Angeles over the past two years.

As part of his journey, Doug smokes, eats and vaporizes medical marijuana for thirty consecutive days in order to get "Super High." But there is a catch -- first Doug must go thirty days without any marijuana and undertakes a number of tests, completing the same tests while medicated and while sober, in an effort to find out what marijuana does and how it really affects people. Along the way, we follow Doug as he goes out on the road to stand up gigs across the country and hangs out with fellow comedians Sarah Silverman, Bob Odenkirk and Patton Oswalt.