L.B. Jeffries is confined to a wheel chair in his appartment, becuase of a broken leg. He is an active man, who is only consoled by the fact that he has a large rear window through which he can spy on all his neighbours, in the high rise appartment block opposite. He soon becomes suspicious of a man, and ends up convinced that he has committed murder. However, convincing his girlfriend Lisa Carol Fremont as well as Lt Thomas J. Doyle is not so straightforward.