When American brothers Todd and Jan Wolfhouse (Erik Stolhanske and Paul Soter) are sent to Germany on a mission to spread their grandfather's ashes at Oktoberfest, they stumble upon a super-secret, centuries-old, underground beer games competition - Beerfest - the Olympics of beer drinking. At Beerfest, the brothers receive a less than warm welcome from their German cousins, the Von Wolfhausens, who shun Todd and Jan, slander their heritage, and worst of all, drink them under the table.

Vowing to return in a year to defend their family honor, the Wolfhouse boys assemble a ragtag dream team of beer drinkers and gamers: Barry Badrinath (Jay Chandrasekhar), a consummate skills player with a dark past; Phil Krundle (Kevin Heffernan) AKA "Landfill," the one-man chugging machine; and Charlie "Fink" Finklestein (Steve Lemme), the lab tech with a Masters degree in All Things Beer. With the inspiration of their Great Gam Gam (Cloris Leachman) and the support of her caretaker, Cherry (Mo'Nique), this "Magnificent Five" train relentlessly, using their hearts, minds and livers to drink faster, smarter and harder than they ever have before.