When inexperienced call girl Alabama Whitman (Patricia Arquette) is paid to seduce comic-book-nerd and Elvis fanatic Clarence Worley (Christian Slater), she doesn't expect to fall for him. But these two lost souls seem to be made for each other and quickly pledge their love, marrying at Detroit's city hall. Clarence discovers some newfound bravado and attempts to retrieve Alabama's possessions from her pimp, Drexl (Gary Oldman), who isn't exactly eager to let Alabama go. Fleeing Drexl's apartment, Clarence not only leaves a trail of bodies, but also inadvertently mistakes a suitcase of uncut cocaine for one with his wife's clothing, and the chase is on.