The film begins where the first film left off, with Alice (Milla Jovovic) in the heart of the ravaged and deadly Raccoon City. Together with other survivors, she must escape what is quickly becoming a City of the Dead. To reach their goal, they will need to battle their way through the relentless onslaught of the ravenous undead, as well as Umbrella forces and terrifying bioengineered weapons, the most deadly of which is the colossal, heavily armed assassin, Nemesis.