Trailer dweller Lou (Natasha Lyonne) and her best friend Sadie (Chloë Sevigny) spend most of their nights steeped in a murky haze of pot smoke and booze-filled TV-watching sessions, venturing out on occasion to party in a desolate community full of drug-addled ex-Marines and other miscreants of society. After an otherwise normal night of self-destructive behavior, Lou awakens with symptoms of a bizarre illness and psychosomatic visions that she can't seem to shake. Unfazed, she continues with her hard-living ways, but even her frequent bong rips don't fully explain the shitstorm swirling around in her head. Something otherworldly has infected her body, and try as she might, it refuses to be ignored. An unknown stranger arrives to help her get a grip on reality as paranoia sets in and stories of conspiracy spread.
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