Derek Noakes (Ricky Gervais) is a tender, innocent man whose love for his job and the people he cares for shines through. He's 49 years old and loves animals, Rolf Harris, Jesus, 'Deal or No Deal', 'Million Pound Drop' and 'Britain's Got Talent' - but his main hobby is autograph hunting. He works in a retirement home with his mate and landlord, Dougie (Karl Pilkington). Derek cares deeply for old people because they're kind and funny and tell him stories about the olden days.
Hannah (Kerry Godliman) is a care worker at the home and is Derek's best friend. She's smart, witty and hard working, but unlucky in love; and like Derek, always puts other people first.