Samantha Newly is a vice-president at a Chicago realty firm. When she gets hit by a car, she falls into a coma. For eight days she is asleep, but upon waking, she finds she has retrograde amnesia; she has retained all general knowledge but hasn't a clue as to who she is or what she's done with her life. Soon, Sam finds out she's been very, very cruel to those around her. Taking her amnesia as a sign that it's time for change, Sam sets about making up for what the old, evil Sam did, and tries to change her life and herself for the better.